A taurine-conjugated form of deoxycholic acid
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Taurodeoxycholic Acid (sodium salt hydrate)

Item No. 15935

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[(3α,5β,12α)-3,12-dihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid, monosodium salt, hydrate
CAS Number
207737-97-1
Synonyms
  • TDCA​
Molecular Formula
C26H44NO6S • Na [XH2O]
Formula Weight
521.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 20 mg/mlEthanol: 2 mg/mlPBS (pH 7.2): 3 mg/ml
SMILES
O[C@@H]1CC[C@@]2(C)[C@@](CC[C@]3([H])[C@]2([H])C[C@H](O)[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC(NCCS(=O)([O-])=O)=O)([H])C1.[Na+].O
InChi Code
InChI=1S/C26H45NO6S.Na.H2O/c1-16(4-9-24(30)27-12-13-34(31,32)33)20-7-8-21-19-6-5-17-14-18(28)10-11-25(17,2)22(19)15-23(29)26(20,21)3;;/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33);;1H2/q;+1;/p-1/t16-,17-,18-,19+,20-,21+,22+,23+,25+,26-;;/m1../s1
InChi Key
OLPIZAYYAVQETM-GGPRKOIFSA-M
Origin
Animal/Bovine bile
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $51

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    5 g

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    25 g

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    Product Description

    Taurodeoxycholic acid is a taurine-conjugated form of the secondary bile acid deoxycholic acid (Item Nos. 20756 | 18231).1 Taurodeoxycholic acid stimulates chloride ion secretion through calcium-activated chloride ion channels and cystic fibrosis transmembrane conductance regulator (CFTR) in Calu-3 airway epithelial cell monolayers when applied basolaterally.2 Serum levels of taurodeoxycholic acid increase approximately 5-fold within two hours during an oral lipid tolerance test in humans.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schmid, A., Neumann, H., Karrasch, T., et al. Bile acid metabolome after an oral lipid tolerance test by liquid chromatography-tandem mass spectrometry (LC-MS/MS). PLoS One 11(2), e0148869 (2016).

    2. Hendrick, S.M., Mroz, M.S., Greene, C.M., et al. Bile acids stimulate chloride secretion through CFTR and calcium-activated Cl- channels in Calu-3 airway epithelial cells. Am. J. Physiol. Lung. Cell. Mol. Physiol. 307(5), L407-L418 (2014).

    Product Citations

    Kaffe, E., Roulis, M., Zhao, J., et al. Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions. Cell 186(18), 3793-3809 (2023).