An internal standard for the quantification of taurodeoxycholic acid
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Taurodeoxycholic Acid-d4 (sodium salt)

Item No. 32983

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[(3α,5β,12α)-3,12-dihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]amino]-ethanesulfonic acid, monosodium salt
CAS Number
2410279-82-0
Synonyms
  • Sodium Taurodeoxycholate-d4
  • TDCA-d4
Molecular Formula
C26H40D4NO6S • Na
Formula Weight
525.7
Purity
≥99% deuterated forms (d1-d4)
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 20 mg/mlEthanol: 2 mg/mlPBS (pH 7.2): 3 mg/ml
SMILES
[H][C@]12[C@@]([C@@](CC[C@]3([H])[C@H](C)CCC(NCCS(=O)([O-])=O)=O)([H])[C@]3(C)[C@@H](O)C2)([H])CC[C@]4([H])C([2H])([2H])[C@H](O)C([2H])([2H])C[C@@]41C.[Na+]
InChi Code
InChI=1S/C26H45NO6S.Na/c1-16(4-9-24(30)27-12-13-34(31,32)33)20-7-8-21-19-6-5-17-14-18(28)10-11-25(17,2)22(19)15-23(29)26(20,21)3;/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33);/q;+1/p-1/t16-,17-,18-,19+,20-,21+,22+,23+,25+,26-;/m1./s1/i10D2,14D2;
InChi Key
YXHRQQJFKOHLAP-YPYHFUETSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $267

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    Product Description

    Taurodeoxycholic acid-d4 is intended for use as an internal standard for the quantification of taurodeoxycholic acid (Item No. 15935) by GC- or LC-MS. Taurodeoxycholic acid is a taurine-conjugated form of the secondary bile acid deoxycholic acid (Item Nos. 20756 | 18231).1 Taurodeoxycholic acid stimulates chloride ion secretion through calcium-activated chloride ion channels and cystic fibrosis transmembrane conductance regulator (CFTR) in Calu-3 airway epithelial cell monolayers when applied basolaterally.2 Serum levels of taurodeoxycholic acid increase approximately 5-fold within two hours during an oral lipid tolerance test in humans.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schmid, A., Neumann, H., Karrasch, T., et al. Bile acid metabolome after an oral lipid tolerance test by liquid chromatography-tandem mass spectrometry (LC-MS/MS). PLoS One 11(2), e0148869 (2016).

    2. Hendrick, S.M., Mroz, M.S., Greene, C.M., et al. Bile acids stimulate chloride secretion through CFTR and calcium-activated Cl- channels in Calu-3 airway epithelial cells. Am. J. Physiol. Lung. Cell. Mol. Physiol. 307(5), L407-L418 (2014).