A Certified Reference Material of taurodeoxycholic acid
Features
  • This product is qualified as a Certified Reference Material (CRM) that has been manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards
  • This CRM has been characterized by metrologically valid procedures and may be used as a quantitative analytical reference standard
  • Certificate of analysis provides the certified property values and the associated uncertainties, including a statement of metrological traceability for the certified values
  • Bulk material is available for qualified institutions; please contact our sales department for pricing
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Taurodeoxycholic Acid (CRM)

Item No. 44869

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[(3α,5β,12α)-3,12-dihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid
CAS Number
516-50-7
Synonyms
  • TDCA
Molecular Formula
C26H45NO6S
Formula Weight
499.7
Formulation (Request formulation change)
A 100 µg/ml solution in methanol
SMILES
O[C@@H]1CC[C@@]2(C)[C@@](CC[C@]3([H])[C@]2([H])C[C@H](O)[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC(NCCS(=O)(O)=O)=O)([H])C1
InChi Code
InChI=1S/C26H45NO6S/c1-16(4-9-24(30)27-12-13-34(31,32)33)20-7-8-21-19-6-5-17-14-18(28)10-11-25(17,2)22(19)15-23(29)26(20,21)3/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17-,18-,19+,20-,21+,22+,23+,25+,26-/m1/s1
InChi Key
AWDRATDZQPNJFN-VAYUFCLWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    100 µg

    $139

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    Product Description

    Taurodeoxycholic acid (CRM) (Item No. 44869) is a certified reference material categorized as a taurine-conjugated secondary bile acid.1 It is produced from cholic acid via gut microbiota followed by taurine conjugation and is involved in the facilitation of digestion and absorption of dietary lipids and fat-soluble vitamins.2 Gastric juice levels of taurodeoxycholic acid are increased in patients with bile reflux gastritis or gastric cancer, and serum levels of taurodeoxycholic acid are decreased in patients with primary biliary cholangitis.3,4 This product is intended for use in quantitative analytical research applications. This product is also available as a general research tool (Item No. 15935).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schmid, A., Neumann, H., Karrasch, T., et al. Bile acid metabolome after an oral lipid tolerance test by liquid chromatography-tandem mass spectrometry (LC-MS/MS). PLoS One 11(2), e0148869 (2016).

    2. de Aguiar Vallim, T.Q., Tarling, E.J., and Edwards, P.A. Pleiotropic roles of bile acids in metabolism. Cell Metab. 17(5), 657-669 (2013).

    3. Wang, S., Kuang, J., Zhang, H., et al. Bile Acid-Microbiome Interaction Promotes Gastric Carcinogenesis. Adv. Sci. (Weinh) 9(16), e2200263 (2022).

    4. Liu, D., Li, G., Liu, D., et al. Quantitative Detection of 15 Serum Bile Acid Metabolic Products by LC/MS/MS in the Diagnosis of Primary Biliary Cholangitis. Chem. Biodivers. 20(3), e202200720 (2023).