An ERK inhibitor
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ERK Inhibitor

Item No. 15944

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-2,4-thiazolidinedione, monohydrochloride
CAS Number
1049738-54-6
Synonyms
  • Extracellular Regulated Kinase Inhibitor
Molecular Formula
C14H16N2O3S • HCl
Formula Weight
328.8
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 2 mg/ml
λmax
238, 354 nm
SMILES
CCOC1=CC=C(/C=C2SC(N(CCN)C\2=O)=O)C=C1.Cl
InChi Code
InChI=1S/C14H16N2O3S.ClH/c1-2-19-11-5-3-10(4-6-11)9-12-13(17)16(8-7-15)14(18)20-12;/h3-6,9H,2,7-8,15H2,1H3;1H/b12-9-;
InChi Key
PQVLWVGMXJPJLG-MWMYENNMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $36

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    1 mg

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    5 mg

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    Product Description

    ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 µM).1 This prevents its interaction with protein substrates without inhibiting catalytic activity.1 ERK inhibitor blocks ERK-specific phosphorylation of ribosomal S6 kinase-1 and ternary complex factor Elk-1 but does not affect ERK1/2 phosphorylation by MEK1/2.1 Presumably through its effects on ERK, ERK inhibitor completely prevents proliferation of HeLa cells (IC50 = 15-20 µM), A549 lung carcinoma cells (IC50 = 25 µM), Sum-159 estrogen receptor-negative breast cancer cells and HT1080 fibrosarcoma cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hancock, C.N., Macias, A., Lee, E.K., et al. Identification of novel extracellular signal-regulated kinase docking domain inhibitors. J. Med. Chem. 48(14), 4586-4595 (2005).