An α2-adrenergic receptor agonist
Related Products
Analytical Standard(s)
38558Clonidine (hydrochloride)
Labeled Version(s)
28519Clonidine-d4 (hydrochloride)
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Clonidine (hydrochloride)

Item No. 15949

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine, monohydrochloride
CAS Number
4205-91-8
Synonyms
  • ST 155
Molecular Formula
C9H9Cl2N3 • HCl
Formula Weight
266.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.3 mg/mlDMSO: 3 mg/mlEthanol: 2 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
ClC1=C(NC2=NCCN2)C(Cl)=CC=C1.Cl
InChi Code
InChI=1S/C9H9Cl2N3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9;/h1-3H,4-5H2,(H2,12,13,14);1H
InChi Key
ZNIFSRGNXRYGHF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 mg

    $36

    Add

    1 g

    $63

    Add

    5 g

    $196

    Add
    Product Description

    Clonidine is an agonist of α2-adrenergic receptors (α2-ARs; Kis = 61.66, 69.18, and 134.9 nM for α2A-, α2B-, and α2C-ARs, respectively).1 It stimulates [35S]GTPγS binding to HEK293 cell membranes expressing the human receptors with EC50 values of 26.92, 56.23, and 912.01 nM for α2A-, α2B-, and α2C-ARs, respectively. Clonidine also binds to I1-imidazoline sites in a variety of cell and tissue types (Kds = 4-15 nM).2 It induces relaxation of isolated mesenteric artery rings precontracted with norepinephrine (Item No. 16673) when used at a concentration of 10 μM.3 Clonidine (10 μM) also induces membrane hyperpolarization and reduces norepinephrine-induced depolarization in isolated mesenteric artery rings. Clonidine (0.1 and 1 μg/kg) reduces mean blood pressure and heart rate when administered via microinjection to the nucleus reticularis lateralis (NRL) of anesthetized normotensive cats.4 Formulations containing clonidine have been used in the treatment of hypertension.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jasper, J.R., Lesnick, J.D., Chang, L.K., et al. Ligand efficacy and potency at recombinant α2 adrenergic receptors: Agonist-mediated [35S]GTPγS binding. Biochem. Pharmacol. 55(7), 1035-1043 (1998).

    2. Ernsberger, P., Graves, M.E., Graff, L.M., et al. I1-imidazoline receptors. Definition, characterization, distribution, and transmembrane signaling. Ann. N. Y. Acad. Sci. 763(1), 22-42 (1995).

    3. Silva, E.G., Feres, T., Vianna, L.M., et al. Dual effect of clonidine on mesenteric artery adrenoceptors: Agonistic (alpha-2) and antagonistic (alpha-1). J. Pharmacol. Exp. Ther. 277(2), 872-876 (1996).

    4. Bousquet, P., Feldman, J., and Schwartz, J. Central cardiovascular effects of alpha adrenergic drugs: Differences between catecholamines and imidazolines. J. Pharmacol. Exp. Ther. 2301(1), 232-236 (1984).