A TRAIL-inducing compound
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TIC10

Item No. 16109

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,4,6,7,8,9-hexahydro-4-[(2-methylphenyl)methyl]-7-(phenylmethyl)-imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one
CAS Number
1616632-77-9
Synonyms
  • Dordaviprone
  • ONC201
Molecular Formula
C24H26N4O
Formula Weight
386.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 1 mg/mlEthanol: 10 mg/ml
λmax
232, 311 nm
SMILES
CC1=CC=CC=C1CN(C2=O)C3=NCCN3C4=C2CN(CC5=CC=CC=C5)CC4
InChi Code
InChI=1S/C24H26N4O/c1-18-7-5-6-10-20(18)16-28-23(29)21-17-26(15-19-8-3-2-4-9-19)13-11-22(21)27-14-12-25-24(27)28/h2-10H,11-17H2,1H3
InChi Key
VLULRUCCHYVXOH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    TIC10 induces the expression of TNF-related apoptosis-inducing ligand (TRAIL) at 1-5 µM in a p53-independent manner.1 It is orally active, stable, and crosses the blood-brain barrier.1 The induction of TRAIL results from dual inhibition of Akt and ERK1/2 combined with nuclear translocation of the transcription factor FOXO3a.1 TIC10 suppresses the growth of orthotopic human glioblastoma multiforme tumors in mice.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Allen, J.E., Krigsfeld, G., Mayes, P.A., et al. Dual inactivation of Akt and ERK by TIC10 signals Foxo3a nuclear translocation, TRAIL gene induction, and potent antitumor effects. Sci. Transl. Med. 5(171), 171ra117 (2013).