A taurine-conjugated form of cholic acid
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Taurocholic Acid (sodium salt)

Item No. 16215

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid, monosodium salt
CAS Number
145-42-6
Synonyms
  • Ethanesulfonic Acid
  • TCA
Molecular Formula
C26H44NO7S • Na
Formula Weight
537.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 20 mg/mlEthanol: mg/mlPBS (pH 7.2): 3 mg/ml
SMILES
O[C@@H]1C[C@]2([H])C[C@H](O)CC[C@]2(C)[C@]3([H])[C@]1([H])[C@@](CC[C@]4([H])[C@@H](CCC(NCCS([O-])(=O)=O)=O)C)([H])[C@]4(C)[C@@H](O)C3.[Na+]
InChi Code
InChI=1S/C26H45NO7S.Na/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29;/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34);/q;+1/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-;/m1./s1
InChi Key
JAJWGJBVLPIOOH-IZYKLYLVSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

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    Product Description

    Taurocholic acid (TCA) is a taurine-conjugated form of the primary bile acid cholic acid (Item No. 20250).1 Serum levels of TCA are decreased in patients with Crohn's disease and those with ulcerative colitis with no extraintestinal manifestations, but are increased in patients with ulcerative colitis accompanied by hepatobiliary disease.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lefebvre, P., Cariou, B., Lien, F., et al. Role of bile acids and bile acid receptors in metabolic regulation. Physiol. Rev. 89(1), 147-191 (2009).

    2. Gnewuch, C., Liebisch, G., Langmann, T., et al. Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease. World J. Gastroenterol. 15(25), 3134-3141 (2009).

    Product Citations

    Kaffe, E., Roulis, M., Zhao, J., et al. Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions. Cell 186(18), 3793-3809 (2023).

    Wei, W., Lyu, X., Markhard, A.L., et al. PTER is a N-acetyltaurine hydrolase that regulates feeding and obesity. Nature 633(8028), 182-188 (2023).