A taurine-conjugated form of ursocholic acid
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Tauroursocholic Acid (sodium salt)

Item No. 43806

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[(3α,5β,7β,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid, monosodium salt
CAS Number
17515-36-5
Synonyms
  • TUCA
Molecular Formula
C26H44NO7S • Na
Formula Weight
537.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Soluble: ≥10 mg/ml
SMILES
C[C@H](CCC(NCCS([O-])(=O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@@]21C.[Na+]
InChi Code
InChI=1S/C26H45NO7S.Na/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29;/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34);/q;+1/p-1/t15-,16+,17-,18-,19+,20+,21+,22+,24+,25+,26-;/m1./s1
InChi Key
JAJWGJBVLPIOOH-NMDOXBRESA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

    $1,089

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    Product Description

    Tauroursocholic acid (TUCA) is a taurine-conjugated form of the bile acid ursocholic acid (Item No. 29883) and the 7β-hydroxy epimer of taurocholic acid (TCA; Item No. 16215).1,2 Unlike TCA, TUCA does not inhibit HMG-CoA reductase nor the cytochrome P450 (CYP) isoform CYP7A1, also known as cholesterol 7α-hydroxylase. Bile levels of TUCA are increased in patients with biliary tract cancer compared with patients with benign biliary diseases.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nguyen, L.B., Shefer, S., Salen, G., et al. Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in the rat ileum: Effects of bile acids and lovastatin. Metabolism 43(11), 1446-1450 (1994).

    2. Shefer, S., Nguyen, L., Salen, G., et al. Feedback regulation of bile-acid synthesis in the rat. Differing effects of taurocholate and tauroursocholate. J. Clin. Invest. 85(4), 1191-1198 (1990).

    3. Xu, X., Cheng, S., Ding, C., et al. Identification of bile biomarkers of biliary tract cancer through a liquid chromatography/mass spectrometry-based metabolomic method. Mol. Med. Rep. 11(3), 2191-2198 (2015).