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VS-5584

Item № 16294
CAS № 1246560-33-7
Purity ≥98%
product image
                (CAS 1246560-33-7)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $25.00 0.00
     5 mg $113.00 0.00
     10 mg $188.00 0.00

Pricing updated 2019-04-24. Prices are subject to change without notice.

Description

Phosphatidylinositol 3-kinase (PI3K) signaling through Akt/PKB and the mammalian target of rapamycin (mTOR) controls gene expression related to cell proliferation, differentiation, and apoptosis. Increased activity of this pathway is important in many types of cancer. VS-5584 is a purine analog that inhibits mTOR (IC50 = 37 nM) and PI3K (IC50s = 16, 68, 25, and 42 nM for the α, β, γ, and δ isoforms, respectively) without relevant activity against more than 400 additional lipid and protein kinases.1 By inhibiting the phosphorylation of substrates downstream of PI3K and mTOR, VS-5584 demonstrates broad anti-proliferative sensitivity leading to tumor growth inhibition in human tumor models.1

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Technical Information
Formal Name
5-[8-methyl-9-(1-methylethyl)-2-(4-morpholinyl)-9H-purin-6-yl]-2-pyrimidinamine
CAS Number
1246560-33-7
Molecular Formula
C17H22N8O
Formula Weight
354.4
Purity
≥98%
Formulation
A crystalline solid
λmax
240, 285, 354 nm
SMILES
CC1=NC(C(C2=CN=C(N)N=C2)=N3)=C(N1C(C)C)N=C3N4CCOCC4
InChI Code
InChI=1S/C17H22N8O/c1-10(2)25-11(3)21-14-13(12-8-19-16(18)20-9-12)22-17(23-15(14)25)24-4-6-26-7-5-24/h8-10H,4-7H2,1-3H3,(H2,18,19,20)
InChI Key
QYBGBLQCOOISAR-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Hart, S., Novotny-Diermayr, V., Goh, K.C., et al. VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer Molecular Cancer Therapeutics 12(2), 151-161 (2013).

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