An alkyne derivative of cholesterol for click chemistry
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Isomer(s)
2431927-alkyne Cholesterol
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19-alkyne Cholesterol

Item No. 16446

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
10-ethynyl-19-norcholest-5-en-3β-ol
CAS Number
2058319-71-2
Synonyms
  • 19-ethynyl Cholesterol
  • Click TagTM 19-alkyne Cholesterol
Molecular Formula
C28H44O
Formula Weight
396.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 0.1 mg/mlEthanol: 20 mg/mlEthanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
SMILES
O[C@H](C1)CC[C@@]2(C#C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCCC(C)C
InChi Code
InChI=1S/C28H44O/c1-6-28-17-14-22(29)18-21(28)10-11-23-25-13-12-24(20(4)9-7-8-19(2)3)27(25,5)16-15-26(23)28/h1,10,19-20,22-26,29H,7-9,11-18H2,2-5H3/t20-,22+,23+,24-,25+,26+,27-,28+/m1/s1
InChi Key
WJAIXDUKNKCGOR-YRPOHEEZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $82

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    5 mg

    $363

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    10 mg

    $685

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    Product Description

    19-alkyne Cholesterol is an alkyne derivative of cholesterol (Item No. 9003100).1 It has been used to track cholesterol localization and subcellular distribution in NIH3T3 cells and to study the role of cholesterol in hedgehog (Hh) signal transduction in Shh-LIGHT2 cells using click chemistry and various reporter azides.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jao, C.Y., Nedelcu, D., Lopez, L.V., et al. Bioorthogonal probes for imaging sterols in cells. Chembiochem 16(4), 611-617 (2015).