An alkyne derivative of cholesterol for click chemistry
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Isomer(s)
1644619-alkyne Cholesterol
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27-alkyne Cholesterol

Item No. 24319

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
20R-[(4R)-4-methyl-5-hexyn-1-yl]-pregn-5-en-3β-ol
CAS Number
1527467-07-7
Synonyms
  • Click Tag™ 27-alkyne Cholesterol
Molecular Formula
C28H44O
Formula Weight
396.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 0.1 mg/mlEthanol: 20 mg/mlEthanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
SMILES
C[C@H](CCC[C@@H](C)C#C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
InChi Code
InChI=1S/C28H44O/c1-6-19(2)8-7-9-20(3)24-12-13-25-23-11-10-21-18-22(29)14-16-27(21,4)26(23)15-17-28(24,25)5/h1,10,19-20,22-26,29H,7-9,11-18H2,2-5H3/t19-,20+,22-,23-,24+,25-,26-,27-,28+/m0/s1
InChi Key
HOUZLWCQDNDNNE-ZRUUVFCLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 µg

    $236

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    250 µg

    $499

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    500 µg

    $876

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    Product Description

    27-alkyne Cholesterol is an alkyne derivative of cholesterol. It has been used to track cholesterol metabolism and localization using click chemistry and various reporter azides in fixed or living cells.1 It is a substrate for enzymes from a variety of species including bacteria, yeast, rat, and human.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hofmann, K., Thiele, C., Schött, H.F., et al. A novel alkyne cholesterol to trace cellular cholesterol metabolism and localization. J. Lipid Res. 55(3), 583-591 (2014).