A dopamine and serotonin receptor antagonist
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Blonanserin

Item No. 16480

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine
CAS Number
132810-10-7
Synonyms
  • AD5423
  • Lonasen
Molecular Formula
C23H30FN3
Formula Weight
367.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlEthanol: 10 mg/ml
λmax
236, 315 nm
SMILES
CCN1CCN(C2=NC(CCCCCC3)=C3C(C4=CC=C(F)C=C4)=C2)CC1
InChi Code
InChI=1S/C23H30FN3/c1-2-26-13-15-27(16-14-26)23-17-21(18-9-11-19(24)12-10-18)20-7-5-3-4-6-8-22(20)25-23/h9-12,17H,2-8,13-16H2,1H3
InChi Key
XVGOZDAJGBALKS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $49

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    10 mg

    $69

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    25 mg

    $154

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    100 mg

    $329

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    Product Description

    Blonanserin is a 4-phenyl-2-(1-piperazinyl) pyridine that acts as an antagonist at dopamine D2, D3, and serotonin 5-HT2A receptors (Kis = 0.14, 0.49, and 0.81 nM, respectively).1 It binds to 5-HT6 with a Ki value of 11.7 nM and demonstrates relatively low affinity for 5-HT2C (Ki = 26.4 nM), adrenergic α1 (Ki = 26.7 nM), histamine H1 (Ki = 765 nM), and muscarinic M1 receptors (Ki = 100 nM).1 Blonanserin was developed in Japan as a novel antipsychotic that displays 20- and 94-fold higher affinity for D2 receptors compared to haloperidol (Item No. 12014) and risperidone (Item No. 13629), respectively.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tenjin, T., Miyamoto, S., Ninomiya, Y., et al. Profile of blonanserin for the treatment of schizophrenia. Neuropsychiatr. Dis. Treat. 9, 587-594 (2013).