An agonist of FP receptors, active metabolite of unoprostone isopropyl ester, and a derivative of PGF2α
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Pro-drug Form(s)
16681Unoprostone isopropyl ester
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Unoprostone

Item No. 16680

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9α,11α-dihydroxy-13,14-dihydro-15-oxo-20a,20b-dihomoprost-5-en-1-oic acid
CAS Number
120373-36-6
Synonyms
  • 13,14-dihydro-15-keto-20-ethyl Prostaglandin F2α
  • 13,14-dihydro-15-keto-20-ethyl PGF2α
  • Unoprostone (free acid)
Molecular Formula
C22H38O5
Formula Weight
382.5
Purity
≥98%
Formulation
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 17 mg/mlEthanol: 12 mg/mlPBS (7.2): 90 µg/ml
SMILES
O[C@@H]1[C@H](C/C=C\CCCC(O)=O)[C@@H](CCC(CCCCCCC)=O)[C@H](O)C1
InChi Code
InChI=1S/C22H38O5/c1-2-3-4-5-8-11-17(23)14-15-19-18(20(24)16-21(19)25)12-9-6-7-10-13-22(26)27/h6,9,18-21,24-25H,2-5,7-8,10-16H2,1H3,(H,26,27)/b9-6-/t18-,19-,20+,21-/m1/s1
InChi Key
TVHAZVBUYQMHBC-SNHXEXRGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Unoprostone is an agonist of FP receptors (EC50 = 4.12 µM), an active metabolite the ocular hypotensive agent unoprostone isopropyl ester (Item No. 16681), and a derivative of prostaglandin F2α (PGF2α; Item Nos. 16010 | 16020).1 It is formed from unoprostone isopropyl ester by hydrolysis. Intravitreal administered unoprostone (1.2, 3.6, or 6 µg/µl) prevents constant light-induced degradation of photoreceptors in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sharif, N.A., Kelly, C.R., Crider, J.Y., et al. Ocular hypotensive FP prostaglandin (PG) analogs: PG receptor subtype binding affinities and selectivities, and agonist potencies at FP and other PG receptors in cultured cells. J. Ocul. Pharmacol. Ther. 19(6), 501-515 (2003).

    2. Hayami , K., and Unoki, K. Photoreceptor protection against constant light-induced damage by isopropyl unoprostone, a prostaglandin F2α metabolite-related compound. Ophthalmic Res. 33(4), 203-209 (2001).