An ocular hypotensive agent, a prodrug form of unoprostone, and a derivative of PGF2α
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Active Metabolite(s)
16680Unoprostone
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Unoprostone isopropyl ester

Item No. 16681

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9α,11α-dihydroxy-13,14-dihydro-15-oxo-20a,20b-dihomoprost-5Z-en-1-oic acid, isopropyl ester
CAS Number
120373-24-2
Synonyms
  • 13,14-dihydro-15-keto-20-ethyl Prostaglandin F2α isopropyl ester
  • UF-021
Molecular Formula
C25H44O5
Formula Weight
424.6
Purity
≥95%
Formulation
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 1 mg/mlEthanol: 15 mg/ml
SMILES
O[C@@H]1[C@H](C/C=C\CCCC(OC(C)C)=O)[C@@H](CCC(CCCCCCC)=O)[C@H](O)C1
InChi Code
InChI=1S/C25H44O5/c1-4-5-6-7-10-13-20(26)16-17-22-21(23(27)18-24(22)28)14-11-8-9-12-15-25(29)30-19(2)3/h8,11,19,21-24,27-28H,4-7,9-10,12-18H2,1-3H3/b11-8-/t21-,22-,23+,24-/m1/s1
InChi Key
XXUPXHKCPIKWLR-JHUOEJJVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $63

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    5 mg

    $283

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    10 mg

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    50 mg

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    Product Description

    Unoprostone isopropyl ester is an ocular hypotensive agent, a prodrug form of the FP receptor agonist unoprostone (Item No. 16680), and a derivative of prostaglandin F2α (PGF2α; Item Nos. 16010 | 16020).1 It inhibits contractions induced by the peptide vasoconstrictor endothelin-1 (Item No. 24127) in isolated porcine retinal arterioles when used at a concentration of 1 nM. Topical application of unoprostone isopropyl ester (0.12% v/v) inhibits increased intraocular pressure induced by the non-selective COX inhibitor indomethacin (Item No. 70270) and increases PGE2 levels in the aqueous humor and aqueous humor outflow in rabbits.2 Formulations containing unoprostone isopropyl ester have been used in the treatment of open-angle glaucoma and ocular hypertension.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yu, D.Y., Su, E.N., Cringle, S.J., et al. Comparison of the vasoactive effects of the docosanoid unoprostone and selected prostanoids on isolated perfused retinal aterioles. Invest. Ophthalmol. Vis. Sci. 42(7), 1499-1504 (2001).

    2. Taniguchi, T., Haque, M.S.R., Sugiyama, K., et al. Ocular hypotensive mechanism of topical isopropyl unoprostone, a novel prostaglandin metabolite-related drug, in rabbits. J. Ocul. Pharmacol. Ther. 12(4), 489-498 (1996).

    Product Citations

    Jeong, H., Lee, D., Jiang, X., et al. Topical application of bunazosin hydrochloride suppresses myopia progression with an increase in choroidal blood perfusion. Invest. Ophthalmol. Vis. Sci. 64(14), 15 (2023).