A tyrosine kinase inhibitor
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CZC-8004

Item No. 16718

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2-[4-(aminomethyl)phenyl]-5-fluoro-N4-phenyl-2,4-pyrimidinediamine
CAS Number
916603-07-1
Synonyms
  • Dianilinopyrimidine-01
Molecular Formula
C17H16FN5
Formula Weight
309.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 5 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: 0.1 mg/ml
λmax
274, 321 nm
SMILES
FC1=CN=C(NC2=CC=C(CN)C=C2)N=C1NC3=CC=CC=C3
InChi Code
InChI=1S/C17H16FN5/c18-15-11-20-17(22-14-8-6-12(10-19)7-9-14)23-16(15)21-13-4-2-1-3-5-13/h1-9,11H,10,19H2,(H2,20,21,22,23)
InChi Key
UKOHFWNBTUJMMN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $90

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    1 mg

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    5 mg

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    10 mg

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    Product Description

    CZC-8004 is an aminopyrimidine that binds a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES.1 It inhibits these kinases at low micromolar concentrations and can be immobilized to capture and purify these enzymes.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Klutchko, S.R., Hamby, J.M., Boschelli, D.H., et al. 2-Substituted aminopyrido[2,3-d]pyrimidin-7(8H)-ones. Structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity. J. Med. Chem. 41(17), 3276-3292 (1998).