A metabolite of thyroid hormone
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3,3'-Diiodo-L-thyronine

Item No. 16748

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine
CAS Number
4604-41-5
Synonyms
  • L-3,3'-Diiodothyronine
  • T2
  • 3,3'-T2
Molecular Formula
C15H13I2NO4
Formula Weight
525.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:30): 0.03 mg/ml
λmax
291 nm
SMILES
OC([C@@H](N)CC1=CC(I)=C(OC2=CC(I)=C(O)C=C2)C=C1)=O
InChi Code
InChI=1S/C15H13I2NO4/c16-10-7-9(2-3-13(10)19)22-14-4-1-8(5-11(14)17)6-12(18)15(20)21/h1-5,7,12,19H,6,18H2,(H,20,21)/t12-/m0/s1
InChi Key
CPCJBZABTUOGNM-LBPRGKRZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    500 µg

    $75

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    1 mg

    $134

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    5 mg

    $589

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    10 mg

    $1,030

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    Product Description

    3,3'-Diiodo-L-thyronine is a metabolite of thyroid hormone that is also known as T2 or 3,3’-T2.1 It is derived enzymatically from triiodothyronine isoforms T3 and reverse T3. T2 and its analog 3,5-T2 stimulate the activity of cytochrome c oxidase by blocking inhibition by ATP.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pinna, G., Hiedra, L., Meinhold, H., et al. 3,3'-Diiodothyronine concentrations in the sera of patients with nonthyroidal illnesses and brain tumors and of healthy subjects during acute stress. J. Clin. Endocrinol. Metab. 83(9), 3071-3077 (1998).

    2. Goglia, F., Lanni, A., Barth, J., et al. Interaction of diiodothyronines with isolated cytochrome c oxidase. FEBS Lett. 346(2-3), 295-298 (1994).

    3. Arnold, S., Goglia, F., and Kadenbach, B. 3,5-Diiodothyronine binds to subunit Va of cytochrome-c oxidase and abolishes the allosteric inhibition of respiration by ATP. Eur. J. Biochem. 252(2), 325-330 (1998).