A thyroid hormone metabolite
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

3,5-Diiodo-L-thyronine

Item No. 35212

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
O-(4-hydroxyphenyl)-3,5-diiodo-L-tyrosine
CAS Number
1041-01-6
Synonyms
  • 3,5-Diiodothyronine
  • NSC 90469
  • 3,5-T2
Molecular Formula
C15H13I2NO4
Formula Weight
525.1
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/ml
λmax
229 nm
SMILES
IC(C=C(C=C1I)C[C@H](N)C(O)=O)=C1OC2=CC=C(C=C2)O
InChi Code
InChI=1S/C15H13I2NO4/c16-11-5-8(7-13(18)15(20)21)6-12(17)14(11)22-10-3-1-9(19)2-4-10/h1-6,13,19H,7,18H2,(H,20,21)/t13-/m0/s1
InChi Key
ZHSOTLOTTDYIIK-ZDUSSCGKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 mg

    $63

    Add

    1 g

    $118

    Add

    5 g

    $363

    Add

    10 g

    $602

    Add
    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    3,5-Diiodo-L-thyronine (3,5-T2) is a thyroid hormone metabolite.1 It binds to thyroid hormone receptor α1 (TRα1), TRβ1, and TRβ2 (EC50s = 0.8, 0.79, and 0.1 µM, respectively, in cell-free assays).2 3,5-T2 (1 pM) stimulates oxygen consumption in perfused livers isolated from rats with hypothyroidism induced by sodium iodide.3 It reduces subcutaneous and epididymal fat mass, as well as decreases serum leptin and cholesterol levels, without affecting body weight in high-fat diet-induced obese mice when administered at a dose of 2.5 µg/g per day.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jonas, W., Lietzow, J., Wohlgemuth, F., et al. 3,5-Diiodo-L-thyronine (3,5-T2) exerts thyromimetic effects on hypothalamus-pituitary-thyroid axis, body composition, and energy metabolism in male diet-induced obese mice. Endocrinology 156(1), 389-399 (2015).

    2. Ball, S.G., Sokolov, J., and Chin, W.W. 3,5-Diiodo-L-thyronine (T2) has selective thyromimetic effects in vivo and in vitro. J. Mol. Endocrinol. 19(2), 137-147 (1997).

    3. Horst, C., Rokos, H., and Seitz, H.J. Rapid stimulation of hepatic oxygen consumption by 3,5-di-iodo-ʟ-thyronine. Biochem. J. 261(3), 945-950 (1989).