A potent and orally bioavailable pan-Akt inhibitor
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AT7867

Item No. 16848

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]-piperidine
CAS Number
857531-00-1
Molecular Formula
C20H20ClN3
Formula Weight
337.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 0.33 mg/ml
λmax
258 nm
SMILES
ClC1=CC=C(C=C1)C2(CCNCC2)C3=CC=C(C4=CNN=C4)C=C3
InChi Code
InChI=1S/C20H20ClN3/c21-19-7-5-18(6-8-19)20(9-11-22-12-10-20)17-3-1-15(2-4-17)16-13-23-24-14-16/h1-8,13-14,22H,9-12H2,(H,23,24)
InChi Key
LZMOSYUFVYJEPY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $117

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    10 mg

    $196

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    25 mg

    $456

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    Product Description

    AT7867 is a potent and orally bioavailable inhibitor of Akt isoforms Akt1, 2, and 3 (IC50s = 32, 17, and 47 nM, respectively).1 It also inhibits p70S6 kinase and PKA (IC50s = 85 and 20 nM, respectively), but is without effect against a panel of other kinases.1 AT7867 inhibits growth and induces apoptosis in a variety of cancer cell lines in vitro and suppresses tumor growth of PTEN-deficient xenografts in mice.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Grimshaw, K.M., Hunter, L.-J.K., Yap, T.A., et al. AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth. Mol. Cancer Ther. 9(5), 1100-1110 (2010).