A nonhydrolyzable GTP analog
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Guanylyl Imidodiphosphate (lithium salt)

Item No. 16880

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5’-guanylic acid, monoanhydride with imidodiphosphoric acid, tetralithium salt
CAS Number
64564-03-0
Molecular Formula
C10H13N6O13P3 • 4Li
Formula Weight
545.9
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
255 nm
SMILES
O[C@H]1[C@H](N2C=NC3=C2N=C(N)NC3=O)O[C@H](COP(OP(NP([O-])([O-])=O)([O-])=O)([O-])=O)[C@H]1O.[Li+].[Li+].[Li+].[Li+]
InChi Code
InChI=1S/C10H17N6O13P3.4Li/c11-10-13-7-4(8(19)14-10)12-2-16(7)9-6(18)5(17)3(28-9)1-27-32(25,26)29-31(23,24)15-30(20,21)22;;;;/h2-3,5-6,9,17-18H,1H2,(H,25,26)(H3,11,13,14,19)(H4,15,20,21,22,23,24);;;;/q;4*+1/p-4/t3-,5-,6-,9-;;;;/m1..../s1
InChi Key
NUKFMILQQVRELO-ZVQJTLEUSA-J
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $52

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    5 mg

    $151

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    10 mg

    $275

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    25 mg

    $556

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    Product Description

    Guanylyl imidodiphosphate is a nonhydrolyzable analog of GTP that can bind to and irreversibly activate G proteins in the presence of Mg2+.1 This nucleotide is a potent stimulator of adenylate cyclase.2 Guanylyl imidodiphosphate is used in studies of protein synthesis since the process of GTP binding, hydrolysis, and release is essential for the initiation of protein translocation across the endoplasmic reticulum.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Terry, B.J., and Purich, D.L. Assembly and disassembly properties of microtubules formed in the presence of GTP, 5'-guanylyl imidodiphosphate, and 5'-guanylyl methylenediphosphate. The Journal of Biological Chemisty 255(21), 10532-10536 (1980).

    2. Lefkowitz, R.J., and Caron, M.G. Characteristics of 5'-guanylyl imidodiphosphate-activated adenylate cyclase. The Journal of Biological Chemisty 250(12), 4418-4422 (1975).

    3. Rapoport, T.A. Transport of proteins across the endoplasmic reticulum membrane. Science 258(5084), 931-936 (1992).