A modified nucleotide
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2-Aminoadenosine-5'-O-triphosphate (sodium salt)

Item No. 38424

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-adenosine 5′-(tetrahydrogen triphosphate), tetrasodium salt
Synonyms
  • 2-amino ATP
  • 2,6-Diaminopurine Riboside-5'-O-triphosphate
Molecular Formula
C10H13N6O13P3 • 4Na
Formula Weight
610.1
Purity
≥95%
Formulation (Request formulation change)
A 10 mM solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O[C@@H]1[C@H](O)[C@@H](COP([O-])(OP(OP([O-])([O-])=O)([O-])=O)=O)O[C@H]1N2C=NC3=C(N)N=C(N)N=C32.[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C10H17N6O13P3.4Na/c11-7-4-8(15-10(12)14-7)16(2-13-4)9-6(18)5(17)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;;;;/h2-3,5-6,9,17-18H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H4,11,12,14,15);;;;/q;4*+1/p-4/t3-,5-,6-,9-;;;;/m1..../s1
InChi Key
RAFPLQGDNSIJNT-ZVQJTLEUSA-J
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    2.6 mg

    $411

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    Product Description

    2-Aminoadenosine-5'-O-triphosphate (2-amino ATP) is a modified nucleotide.1 It promotes microtubule assembly in vitro.2 2-amino ATP has been used as an alternative substrate for T4 DNA ligase in ligase-catalyzed oligonucleotide polymerizations with 96.6% fidelity.3 Incorporation of 2-amino ATP into complementary RNA (cRNA) increases signal detection in microarrays.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nguyen, A., Zhao, C., Dorris, D., et al. Quantitative assessment of the use of modified nucleoside triphosphates in expression profiling: Differential effects on signal intensities and impacts on expression ratios. BMC Biotechnol. 2, 14 (2002).

    2. Muraoka, M., and Sakai, H. Effects of purinenucleotide analogues on microtubule assembly. Cell Struct. Funct. 24(5), 305-312 (1999).

    3. Lei, Y., and Hili, R. Structure-activity relationships of the ATP cofactor in ligase-catalysed oligonucleotide polymerisations. Org. Biomol. Chem. 15(11), 2349-2352 (2017).