A glycine-conjugated form of chenodeoxycholic acid
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Glycochenodeoxycholic Acid (sodium salt hydrate)

Item No. 16942

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(3α,5β,7α)-3,7-dihydroxy-24-oxocholan-24-yl]-glycine, monosodium salt, hydrate
Synonyms
  • GCDCA
Molecular Formula
C26H42NO5 • Na [XH2O]
Formula Weight
471.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 10 mg/mlEthanol: 15 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
O[C@@H]1CC[C@@]2(C)[C@@](C[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC(NCC([O-])=O)=O)([H])C1.[Na+].O
InChi Code
InChI=1S/C26H43NO5.Na.H2O/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29;;/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32);;1H2/q;+1;/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-;;/m1../s1
InChi Key
DPKVEQOULFKWCR-KZRRTRIISA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $36

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    50 mg

    $53

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    100 mg

    $63

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    500 mg

    $203

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    Product Description

    Glycochenodeoxycholic acid (GCDCA) is a glycine-conjugated form of the primary bile acid chenodeoxycholic acid (Item No. 10011286).1 It reduces formation of cholic acid (Item No. 20250) in primary human hepatocytes when used at a concentration of 100 µM.2 GCDCA (50, 75, and 100 µM) reduces the number of LC3 puncta, a marker of autophagy, and is cytotoxic to L-02 hepatocytes.1 GCDCA (50 µM) induces apoptosis in isolated rat hepatocytes, an effect that can be blocked by the protein kinase C (PKC) inhibitor chelerythrine (Item No. 11314).3 Fecal levels of GCDCA are decreased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lan, W., Chen, Z., Chen, Y., et al. Glycochenodeoxycholic acid impairs transcription factor E3-dependent autophagy-lysosome machinery by disrupting reactive oxygen species homeostasis in L02 cells. Toxicol. Lett. 331, 11-21 (2020).

    2. Ellis, E., Axelson, M., Abrahamsson, A., et al. Feedback regulation of bile acid synthesis in primary human hepatocytes: Evidence that CDCA is the strongest inhibitor. Hepatology 38(4), 930-938 (2003).

    3. Gonzalez, B., Fisher, C., and Rosser, B.G. Glycochenodeoxycholic acid (GCDC) induced hepatocyte apoptosis is associated with early modulation of intracellular PKC activity. Mol. Cell. Biochem. 207(1-2), 19-27 (2000).

    4. Lin, H., An, Y., Tang, H., et al. Alterations of bile acids and gut microbiota in obesity induced by high fat diet in rat model. J. Agric. Food Chem. 67(13), 3624-3632 (2019).

    Product Citations

    Liu, R., Rabow, Z.T., Yang, T., et al. Mechanism-guided untargeted-to-targeted lipidomics identifies phosphatidylcholine 38:4 in rat bile as an Abcb4/Mdr2 inhibition marker. Drug Metab. Dispos. 54, 100256 (2026).