An inhibitor of the gastric H+/K+ ATPase and an enantiomer of esomeprazole
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(R)-Omeprazole (sodium salt)

Item No. 18874

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-methoxy-2-[(R)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, monosodium salt
CAS Number
161796-77-6
Synonyms
  • ​(R)-OMEP
  • (R)-OMP
  • (R)-OMZ
Molecular Formula
C17H19N3O3S • Na
Formula Weight
368.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
302 nm
SMILES
COC1=CC=C2C(N=C([S@@](CC3=C(C)C(OC)=C(C)C=N3)=O)N2)=C1.[Na]
InChi Code
InChI=1S/C17H19N3O3S.Na/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;/h5-8H,9H2,1-4H3,(H,19,20);/t24-;/m1./s1
InChi Key
HVAJOLFRLWQQQL-GJFSDDNBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $90

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    1 mg

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    5 mg

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    Product Description

    (R)-Omeprazole is an inhibitor of the gastric H+/K+ ATPase and an enantiomer of esomeprazole (Item No. 17303).1 It inhibits acid secretion induced by histamine (Item No. 33828) in isolated rabbit gastric glands (IC50 = 781 µM) to a lesser extent than esomeprazole. (R)-Omeprazole (30 mg/kg) inhibits histamine-induced stomach acid secretions in rats.2 Formulations containing (R)-omeprazole have been used in the treatment of duodenal and gastric ulcers, gastroesophageal reflux disease (GERD), and erosive esophagitis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Erlandsson, P., Isaksson, R., Lorentzon, P., et al. Resolution of the enantiomers of omeprazole and some of its analogues by liquid chromatography on a trisphenylcarbamoylcellulose-based stationary phase. The effect of the enantiomers of omeprazole on gastric glands. J. Chromatogr. 532(2), 305-319 (1990).

    2. Shin, J.M., and Sachs, G. Restoration of acid secretion following treatment with proton pump inhibitors. Gastroenterology 123(5), 1588-1597 (2002).