An H+/K+-ATPase inhibitor
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Esomeprazole

Item No. 40851

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
CAS Number
119141-88-7
Synonyms
  • (−)-Omeprazole
  • (S)-Omeprazole
Molecular Formula
C17H19N3O3S
Formula Weight
345.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
COC1=CC=C2C(N=C([S@](CC3=C(C)C(OC)=C(C)C=N3)=O)N2)=C1
InChi Code
InChI=1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)/t24-/m0/s1
InChi Key
SUBDBMMJDZJVOS-DEOSSOPVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    50 mg

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    Product Description

    Esomeprazole is an inhibitor of the gastric H+/K+-ATPase and the (S) enantiomer of omeprazole (Item No. 14880).1 It reversibly inhibits the activity of the H+/K+-ATPase in an enzyme assay. Esomeprazole (30 mg/kg, s.c.) inhibits histamine-induced gastric acid secretion in rats. Formulations containing esomeprazole in complex with magnesium have been used as proton pump inhibitors (PPIs) in the treatment of gastroesophageal reflux disease (GERD), H. pylori eradication, and hypersecretory conditions, as well as in the prevention of non-steroidal anti-inflammatory drug-related gastric ulcer.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shin, J.M., and Sachs, G. Restoration of acid secretion following treatment with proton pump inhibitors. Gastroenterology 123(5), 1588-1597 (2002).