An inhibitor of yeast cyclin-dependent kinases
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NG 52

Item No. 17309

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-ethanol
CAS Number
212779-48-1
Synonyms
  • Compound 52
Molecular Formula
C16H19ClN6O
Formula Weight
346.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 15 mg/mlDMSO:PBS (pH 7.2) (1:7): 0.1 mg/mlEthanol: 5 mg/ml
λmax
215, 260, 313 nm
SMILES
CC(C)N1C2=NC(NCCO)=NC(NC3=CC=CC(Cl)=C3)=C2N=C1
InChi Code
InChI=1S/C16H19ClN6O/c1-10(2)23-9-19-13-14(20-12-5-3-4-11(17)8-12)21-16(18-6-7-24)22-15(13)23/h3-5,8-10,24H,6-7H2,1-2H3,(H2,18,20,21,22)
InChi Key
XZEFMZCNXDQXOZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $41

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    1 mg

    $69

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    5 mg

    $293

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    10 mg

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    Product Description

    NG 52 is a tri-substituted purine that binds to the ATP-binding site of yeast cyclin-dependent kinases, inhibiting Cdc28p and Pho85p (IC50s = 7 and 2 µM, respectively).1 It is ineffective against the yeast kinases Kin28p, Srb10, and Cak1p. NG 52 is cell permeable and inhibits the growth of S. cerevisiae (GI50 = 30 µM).1 It is an analog of purvalanol A (Item No. 14579), a potent inhibitor of mammalian cyclin-dependent kinases.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gray, N.S., Wodicka, L., Thunnissen, A.M.W.H., et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science 281(5376), 533-538 (1998).