A muscarinic M1, M2, and M3 receptor antagonist
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Solifenacin (succinate)

Item No. 17320

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
butanedioic acid, compd. with (1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate
CAS Number
242478-38-2
Synonyms
  • YM-67905
Molecular Formula
C23H26N2O2 • C4H6O4
Formula Weight
480.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C(O[C@H]1CN2CCC1CC2)N3[C@@H](C4=CC=CC=C4)C5=CC=CC=C5CC3.OC(CCC(O)=O)=O
InChi Code
InChI=1S/C23H26N2O2.C4H6O4/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19;5-3(6)1-2-4(7)8/h1-9,18,21-22H,10-16H2;1-2H2,(H,5,6)(H,7,8)/t21-,22-;/m0./s1
InChi Key
RXZMMZZRUPYENV-VROPFNGYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $36

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    25 mg

    $53

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    50 mg

    $95

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    100 mg

    $169

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    Product Description

    Solifenacin is a competitive antagonist of M1, M2, and M3 muscarinic acetylcholine receptors (Kis = 25, 125, and 10 nM, respectively, for the human receptors).1 It inhibits calcium mobilization induced by carbachol (carbamoylcholine; Item No. 14486) in isolated guinea pig detrusor muscle cells (Ki = 4 nM).2 Solifenacin inhibits carbachol-induced contraction of isolated guinea pig urinary bladder smooth muscle. In vivo, solifenacin (0.03-1 mg/kg) inhibits carbachol-induced increases in urinary bladder pressure in anesthetized rats. Formulations containing solifenacin have been used in the treatment of overactive bladder.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hegde, S.S. Muscarinic receptors in the bladder: From basic research to therapeutics. Br. J. Pharmacol. 147(2), S80-S87 (2006).

    2. Ikeda, K., Koboyashi, S., Suzuki, M., et al. M3 receptor antagonism by the novel antimuscarinic agent solifenacin in the urinary bladder and salivary gland. Naunyn Schmiedebergs Arch. Pharmacol. 366(2), 97-103 (2002).