An internal standard for the quantification of solifenacin
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Unlabeled Version(s)
17320Solifenacin (succinate)
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Solifenacin-d5 (succinate)

Item No. 34245

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
butanedioic acid, compd. with (1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4-dihydro-1-(phenyl-2,3,4,5,6-d5)-2(1H)-isoquinolinecarboxylate
Molecular Formula
C23H21D5N2O2 • C4H6O4
Formula Weight
485.6
Purity
≥99% deuterated forms (d1-d5)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleMethanol: solubleWater: soluble
SMILES
O=C(O[C@H]1CN2CCC1CC2)N3[C@@H](C4=C([2H])C([2H])=C([2H])C([2H])=C4[2H])C5=CC=CC=C5CC3.OC(CCC(O)=O)=O
InChi Code
InChI=1S/C23H26N2O2.C4H6O4/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19;5-3(6)1-2-4(7)8/h1-9,18,21-22H,10-16H2;1-2H2,(H,5,6)(H,7,8)/t21-,22-;/m0./s1/i1D,2D,3D,7D,8D;
InChi Key
RXZMMZZRUPYENV-BCZWPACGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $105

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    1 mg

    $179

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    5 mg

    $836

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    Product Description

    Solifenacin-d5 is intended for use as an internal standard for the quantification of solifenacin (Item No. 17320) by GC- or LC-MS. Solifenacin is a competitive antagonist of M1, M2, and M3 muscarinic acetylcholine receptors (Kis = 25, 125, and 10 nM, respectively, for the human receptors).1 It inhibits calcium mobilization induced by carbamoylcholine (carbachol; Item No. 14486) in isolated guinea pig detrusor muscle cells (Ki = 4 nM).2 Solifenacin inhibits carbachol-induced contraction of isolated guinea pig urinary bladder smooth muscle. In vivo, solifenacin (0.03-1 mg/kg) inhibits carbachol-induced increases in urinary bladder pressure in anesthetized rats. Formulations containing solifenacin have been used in the treatment of overactive bladder.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hegde, S.S. Muscarinic receptors in the bladder: From basic research to therapeutics. Br. J. Pharmacol. 147(2), S80-S87 (2006).

    2. Ikeda, K., Koboyashi, S., Suzuki, M., et al. M3 receptor antagonism by the novel antimuscarinic agent solifenacin in the urinary bladder and salivary gland. Naunyn Schmiedebergs Arch. Pharmacol. 366(2), 97-103 (2002).