A 53BP1 antagonist
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UNC2170 (maleate)

Item No. 17374

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-bromo-N-[3-[(1,1-dimethylethyl)amino]propyl]-benzamide, 2Z-butenedioate
CAS Number
2173992-60-2
Molecular Formula
C14H21BrN2O • C4H4O4
Formula Weight
429.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
BrC1=CC=CC(C(NCCCNC(C)(C)C)=O)=C1.OC(/C=C\C(O)=O)=O
InChi Code
InChI=1S/C14H21BrN2O.C4H4O4/c1-14(2,3)17-9-5-8-16-13(18)11-6-4-7-12(15)10-11;5-3(6)1-2-4(7)8/h4,6-7,10,17H,5,8-9H2,1-3H3,(H,16,18);1-2H,(H,5,6)(H,7,8)/b;2-1-
InChi Key
WCAATDGMINWXPJ-BTJKTKAUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $53

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    5 mg

    $205

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    10 mg

    $382

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    25 mg

    $825

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    Product Description

    p53-Binding protein 1 (53BP1) binds to dimethylated lysine 20 on histone 4 (H4K20me2) via tandem tudor domains on a 53BP1 homodimer.1 This interaction is an important part of the DNA damage response.1 UNC2170 is a micromolar ligand of 53BP1 that binds to a pocket formed by the tandem tudor domains.2 It displays at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins.2 UNC2170 functions as a 53BP1 antagonist in cellular lysates and shows cellular activity by suppressing class switch recombination, a process which requires a functional 53BP1 tudor domain.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Botuyan, M.V., Lee, J., Ward, I.M., et al. Structural basis for the methylation state-specific recognition for histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell 127(7), 1361-1373 (2006).

    2. Perfetti, M.T., Baughman, B.M., Dickson, B.M., et al. Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. ACS Chem. Biol. 10(4), 1072-1081 (2015).