A 53BP1 antagonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

UNC2170 (maleate)

Item No. 17374

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-bromo-N-[3-[(1,1-dimethylethyl)amino]propyl]-benzamide, 2Z-butenedioate
CAS Number
2173992-60-2
Molecular Formula
C14H21BrN2O • C4H4O4
Formula Weight
429.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
BrC1=CC=CC(C(NCCCNC(C)(C)C)=O)=C1.OC(/C=C\C(O)=O)=O
InChi Code
InChI=1S/C14H21BrN2O.C4H4O4/c1-14(2,3)17-9-5-8-16-13(18)11-6-4-7-12(15)10-11;5-3(6)1-2-4(7)8/h4,6-7,10,17H,5,8-9H2,1-3H3,(H,16,18);1-2H,(H,5,6)(H,7,8)/b;2-1-
InChi Key
WCAATDGMINWXPJ-BTJKTKAUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $53

    Add

    5 mg

    $205

    Add

    10 mg

    $382

    Add

    25 mg

    $825

    Add
    Product Description

    p53-Binding protein 1 (53BP1) binds to dimethylated lysine 20 on histone 4 (H4K20me2) via tandem tudor domains on a 53BP1 homodimer.1 This interaction is an important part of the DNA damage response.1 UNC2170 is a micromolar ligand of 53BP1 that binds to a pocket formed by the tandem tudor domains.2 It displays at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins.2 UNC2170 functions as a 53BP1 antagonist in cellular lysates and shows cellular activity by suppressing class switch recombination, a process which requires a functional 53BP1 tudor domain.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Botuyan, M.V., Lee, J., Ward, I.M., et al. Structural basis for the methylation state-specific recognition for histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell 127(7), 1361-1373 (2006).

    2. Perfetti, M.T., Baughman, B.M., Dickson, B.M., et al. Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. ACS Chem. Biol. 10(4), 1072-1081 (2015).