Endothall

Endothall is an aquatic plant growth regulator.¹ It reduces curly leaf pondweed appearance frequency and dry biomass in lakes when applied annually at a concentration of 1 mg/L. Endothall reduces leaf chlorophyll content in A. thaliana plants and root length in A. thaliana seedlings (IC₅₀s = 1.36 mM and 13.9 µM, respectively) and decreases duckweed growth rate (IC₅₀ = 10 µM).² It induces production of ethylene in bean leaves when applied at a concentration of 1 µM.³ Endothall is also an inhibitor of protein phosphatase 2A (PP2A; IC₅₀ = 19-50 nM).⁴ It is toxic to mice (LD₅₀ = 5-50 mg/kg). Formulations containing endothall have been used in the control of plants in aquatic environments.

WARNING This product is not for human or veterinary use.

1. Johnson, J.A., Jones, A.R., and Newman, R.M. Evaluation of lakewide, early season herbicide treatments for controlling invasive curlyleaf pondweed (Potamogeton crispus) in Minnesota lakes. Lake Reserv. Manag. 28(4), 346-363 (2012).

2. Bajsa, J., Pan, Z., Dayan, F.E., et al. Validation of serine/threonine protein phosphatase as the herbicide target site of endothall. Pestic. Biochem. Physiol. 102(1), 38-44 (2012).

3. Abeles, A.L., and Abeles, F.B. Biochemical pathway of stress-induced ethylene. Plant Physiol. 50(4), 496-498 (1972).

4. Li, Y.-M., and Casida, J.E. Cantharidin-binding protein: Identification as protein phosphatase 2A. Proc. Natl. Acad. Sci. USA 89(24), 11867-11870 (1992).