A typical antipsychotic
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cis-Flupenthixol (hydrochloride)

Item No. 17634

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[3-[(3Z)-2-(trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanol, dihydrochloride
CAS Number
51529-01-2
Synonyms
  • cis-Flupentixol
Molecular Formula
C23H25F3N2OS • 2HCl
Formula Weight
507.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 25 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
230 nm
SMILES
OCCN(CC1)CCN1CC/C=C2C3=C(C=CC(C(F)(F)F)=C3)SC4=CC=CC=C4\2.Cl.Cl
InChi Code
InChI=1S/C23H25F3N2OS.2ClH/c24-23(25,26)17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)30-22)5-3-9-27-10-12-28(13-11-27)14-15-29;;/h1-2,4-8,16,29H,3,9-15H2;2*1H/b18-5-;;
InChi Key
IOVDQEIIMOZNNA-MHKBYHAFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    Product Description

    cis-Flupenthixol is a typical antipsychotic, a dopamine D2 receptor antagonist (Ki = 0.38 nM), and an inverse agonist at the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 7 nM).1 In vivo, cis-flupenthixol (0.5 mg/kg, i.p.) reduces cocaine-induced locomotor activity and prevents development of conditioned place preferences for the immediate effects of intravenously administered cocaine without affecting development of conditioned place aversions in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Seeman, P. Atypical antipsychotics: Mechanism of action. Can. J. Psychiatry 47(1), 27-38 (2002).

    2. Wenzel, J.M., Su, Z.I., Shelton, K., et al. The dopamine antagonist cis-flupenthixol blocks the expression of the conditioned positive but not the negative effects of cocaine in rats. Pharmacol. Biochem. Behav. 114-115, 90-96 (2013).