A histamine H1 receptor antagonist
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Labeled Version(s)
26115Fexofenadine-d10 (hydrochloride)
Pro-drug Form(s)
20305Terfenadine
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Fexofenadine (hydrochloride)

Item No. 18191

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethyl-benzeneacetic acid, monohydrochloride
CAS Number
153439-40-8
Synonyms
  • MDL 16455A
Molecular Formula
C32H39NO4 • HCl
Formula Weight
538.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 12 mg/mlEthanol: 12 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
OC(C1=CC=CC=C1)(C2=CC=CC=C2)C3CCN(CCCC(O)C4=CC=C(C(C)(C)C(O)=O)C=C4)CC3.Cl
InChi Code
InChI=1S/C32H39NO4.ClH/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27;/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36);1H
InChi Key
RRJFVPUCXDGFJB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    50 mg

    $213

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    100 mg

    $329

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    Product Description

    Fexofenadine is a histamine H1 receptor antagonist (Ki = 10 nM).1 It reverses contraction of isolated rat tracheal strips induced by acetyl-β-methylcholine (Item No. 23092).2 Fexofenadine inhibits expression of IL-8 in TNF-α-stimulated HCT116 and COLO 205 cells.3 Oral administration of fexofenadine (2 and 10 mg/kg) reduces severity of colitis and phospho-IκB kinase activation in a mouse model of colitis induced by dextran sulfate sodium (DSS; Item No. 23250).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Church, M.K., and Church, D.S. Pharmacology of antihistamines. Indian J. Dermatol. 58(3), 219-224 (2013).

    2. Lai, W.S., Lin, Y.Y., Chu, Y.H., et al. Efficacy of fexofenadine in isolated rat tracheas. Rhinology 51(4), 376-380 (2013).

    3. Koh, S.J., Kim, J.W., Kim, B.G., et al. Fexofenadine regulates nuclear factor-κB signaling and endoplasmic reticulum stress in intestinal epithelial cells and ameliorates acute and chronic colitis in mice. J. Pharmacol. Exp. Ther. 352(3), 455-461 (2015).