An inhibitor of Akt2
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CCT128930

Item No. 18194

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(4-chlorophenyl)methyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinamine
CAS Number
885499-61-6
Molecular Formula
C18H20ClN5
Formula Weight
341.8
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 5 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
220, 286 nm
SMILES
ClC(C=C1)=CC=C1CC(CC2)(N)CCN2C3=C4C(NC=C4)=NC=N3
InChi Code
InChI=1S/C18H20ClN5/c19-14-3-1-13(2-4-14)11-18(20)6-9-24(10-7-18)17-15-5-8-21-16(15)22-12-23-17/h1-5,8,12H,6-7,9-11,20H2,(H,21,22,23)
InChi Key
RZIDZIGAXXNODG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    CCT128930 is an ATP-competitive inhibitor of Akt2 (IC50 = 6 nM).1 It is selective for Akt over a panel of 47 other kinases, including the related protein kinase A and p70S6K.1 CCT128930 blocks the phosphorylation of Akt targets, inhibits proliferation of multiple tumor cell lines in vitro, and prevents the growth of human tumor xenografts in mice.1 CCT128930 has been used to elucidate the role of Akt2 in regulating the function of interacting proteins, modulating DNA damage and autophagy in HepG2 hepatoma cells, and cell survival and vasculogenesis in endothelial colony forming cells.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yap, T.A., Walton, M.I., Hunter, L.J.K., et al. Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930. Mol. Cancer Ther. 10(2), 360-371 (2011).

    2. Bottermann, K., Reinartz, M., Barsoum, M., et al. Systematic analysis reveals elongation factor 2 and α-enolase as novel interaction partners of AKT2. PLoS One 8(6), 1-12 (2013).

    3. Wang, F.Z., Chang, Z.Y., Fei, H.R., et al. CCT128930 induces cell cycle arrest, DNA damage, and autophagy independent of Akt inhibition. Biochimie. 103, 118-125 (2014).

    4. Kim, H., Prasain, N., Vemula, S., et al. Human platelet lysate improves human cord blood derived ECFC survival and vasculogenesis in three dimensional (3D) collagen matrices. Microvasc. Res. 101, 72-81 (2015).