A naturally occurring estrogen
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Estetrol (hydrate)

Item No. 18232

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
estra-1,3,5(10)-triene-3,15α,16α,17β-tetrol, hydrate
Synonyms
  • E4
  • 15α-Hydroxyestriol
Molecular Formula
C18H24O4 • XH2O
Formula Weight
304.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 20 mg/mlEthanol: 5 mg/ml
SMILES
OC1=CC(CC[C@]2([H])[C@]3([H])CC[C@@]4(C)[C@@]2([H])[C@@H](O)[C@@H](O)[C@@H]4O)=C3C=C1.O
InChi Code
InChI=1S/C18H24O4.H2O/c1-18-7-6-12-11-5-3-10(19)8-9(11)2-4-13(12)14(18)15(20)16(21)17(18)22;/h3,5,8,12-17,19-22H,2,4,6-7H2,1H3;1H2/t12-,13-,14-,15-,16-,17+,18+;/m1./s1
InChi Key
XRJNAPXFAXBPAM-BVTDNVAGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $49

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    1 mg

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    5 mg

    $213

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    Product Description

    Estetrol is an estrogen steroid hormone exclusively produced by fetal liver from estradiol (Item No. 10006315) and estriol (Item No. 10006484) during pregnancy. It binds to estrogen receptors (ERs) with 4-fold higher affinity for ERα over ERβ and exhibits estrogenic effects in most tissues expressing ERs (bone, brain, vagina, and endometrium).1,2 In breast tumors, however, estetrol acts as an estrogen antagonist in the presence of estradiol, preventing tumor growth.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Coelingh Bennink, H.J.T., Holinka, C.F., and Diczfalusy, E. Estetrol review: Profile and potential clinical applications. Climacteric. 11(Suppl 1), 47-58 (2008).

    2. Giretti, M.S., Guevara, M.M.M., Cecchi, E., et al. Effects of Estetrol on Migration and Invasion in T47-D Breast Cancer Cells through the Actin Cytoskeleton. Front. Endocrinol. (Lausanne) 5(80), 1-8 (2014).