A chalconoid with anti-inflammatory and anti-tumor activity
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Cardamonin

Item No. 18310

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one
CAS Number
19309-14-9
Synonyms
  • Alpinetin chalcone
  • Cardamomin
Molecular Formula
C16H14O4
Formula Weight
270.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlDMSO:PBS (pH 7.2) (1:4): 0.2 mg/mlEthanol: 1 mg/ml
λmax
343 nm
SMILES
OC1=C(C(/C=C/C2=CC=CC=C2)=O)C(OC)=CC(O)=C1
InChi Code
InChI=1S/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7+
InChi Key
NYSZJNUIVUBQMM-BQYQJAHWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $65

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    10 mg

    $124

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    25 mg

    $260

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    50 mg

    $488

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    Cayman Chemical
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    Product Description

    Cardamonin, isolated from the fruits of Alpinia species, is a chalconoid with anti-inflammatory and anti-tumor activity.1,2 It has been shown to suppress nitric oxide and prostaglandin E2 synthesis, to suppress cyclooxygenase-2 expression, and to inhibit NF-κB signaling.1,2 It can also target the Bcl-2 protein, inducing apoptosis in cancer cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yadav, V.R., Prasad, S., Sung, B., et al. The role of chalcones in suppression of NF-κB-mediated inflammation and cancer. Int. Immunopharmacol. 11(3), 295-309 (2011).

    2. Sung, B., Prasad, S., Yadav, V.R., et al. Cancer cell signaling pathways targeted by spice-derived nutraceuticals. Nutr. Cancer 64(2), 173-197 (2012).