A chalcone with diverse biological activities
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2'-O-Methylisoliquiritigenin

Item No. 36490

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(4-hydroxy-2-methoxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one
CAS Number
51828-10-5
Molecular Formula
C16H14O4
Formula Weight
270.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/mlMethanol: Sparingly Soluble: 1-10 mg/ml
SMILES
O=C(C1=CC=C(C=C1OC)O)C=CC2=CC=C(C=C2)O
InChi Code
InChI=1S/C16H14O4/c1-20-16-10-13(18)7-8-14(16)15(19)9-4-11-2-5-12(17)6-3-11/h2-10,17-18H,1H3
InChi Key
PACBGANPVNHGNP-UHFFFAOYSA-N
Origin
Plant/Caesalpinia sinensis
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $87

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    5 mg

    $392

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    10 mg

    $653

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    Cayman Chemical
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    Product Description

    2'-O-Methylisoliquiritigenin is a chalcone that has been found in C. sappan and has diverse biological activities.1,2 It reduces colony formation and induces apoptosis and cell cycle arrest at the G2/M phase in HCC827 non-small cell lung cancer (NSCLC) cells when used at a concentration of 12 µM.1 2'-O-Methylisoliquiritigenin induces reactive oxygen species (ROS) production and mitochondrial membrane depolarization in HCC827 cells. It inhibits UV radiation-induced increases in dorsal skin thickness in mice when applied topically at doses of 0.5 or 1 µmol/mouse.2 2'-O-Methylisoliquiritigenin (10 or 20 mg/kg) decreases tumor volume and weight in a SK-MEL-2 melanoma mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, J.-Y., Lee, S.-O., Kwak, A.-W., et al. 3-Deoxysappanchalcone inhibits cell growth of gefitinib-resistant lung cancer cells by simultaneous targeting of EGFR and MET kinases. Biomol. Ther. (Seoul) 31(4), 446-455 (2023).

    2. Fu, X., Zhao, R., Yoon, G., et al. 3-Deoxysappanchalcone inhibits skin cancer proliferation by regulating T-lymphokine-activated killer cell-originated protein kinase in vitro and in vivo. Front. Cell Dev. Biol. 9:638174, (2021).