A chalcone with diverse biological activities
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Pinostrobin Chalcone

Item No. 43023

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E)-1-(2,6-dihydroxy-4-methoxyphenyl)-3-phenyl-2-propen-1-one
CAS Number
18956-15-5
Synonyms
  • ​2′,6′-Dihydroxy 4′-methoxychalcone
  • DMC
Molecular Formula
C16H14O4
Formula Weight
270.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
O=C(C1=C(C=C(C=C1O)OC)O)/C=C/C2=CC=CC=C2
InChi Code
InChI=1S/C16H14O4/c1-20-12-9-14(18)16(15(19)10-12)13(17)8-7-11-5-3-2-4-6-11/h2-10,18-19H,1H3/b8-7+
InChi Key
CUGDOWNTXKLQMD-BQYQJAHWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $55

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    5 mg

    $248

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    10 mg

    $440

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    Product Description

    Pinostrobin chalcone is a chalcone that has been found in H. cymosum and has diverse biological activities.1,2,3,4 It reduces ferric to ferrous iron in a ferric reducing antioxidant power (FRAP) assay (IC50 = 334 µM).1 Pinostrobin chalcone is an inhibitor of α-glucosidase (IC50 = 12.94 µM). It decreases the proliferation of L. amazonensis promastigotes when used at a concentration of 1 µg/ml.2 Pinostrobin chalcone is cytotoxic to KB squamous cell carcinoma, MCF-7 breast, Ca Ski cervical, and HCT116 colorectal cancer cells (IC50s = 6.2, 7.3, 7.7, and 54.1 µM, respectively).3 It inhibits LPS-induced increases in TNF-α and IL-1β in J774A.1 macrophages (IC50s = 69 and 43 µM, respectively).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jadalla, B.M.I.S., Moser, J.J., Sharma, R., et al. In vitro alpha-glucosidase and alpha-amylase inhibitory activities and antioxidant capacity of Helichrysum cymosum and Helichrysum pandurifolium schrank constituents. Separations 9(8), 190 (2022).

    2. Torres-Santos, E.C., Moreira, D.L., Kaplan, M.A., et al. Selective effect of 2',6'-dihydroxy-4'-methoxychalcone isolated from Piper aduncum on Leishmania amazonensis. Antimicrob Agents Chemother. 43(5), 1234-1241 (1999).

    3. Malek, S.N., Phang, C.W., Ibrahim, H., et al. Phytochemical and cytotoxic investigations of Alpinia mutica rhizomes. Molecules 16(1), 583-589 (2011).

    4. Patel, N.K., and Bhutani, K.K. Pinostrobin and Cajanus lactone isolated from Cajanus cajan (L.) leaves inhibits TNF-α and IL-1 production: In vitro and in vivo experimentation. Phytomedicine 21(7), 946-953 (2014).