An Analytical Reference Material
Features
  • This product is qualified as a Reference Material that has been manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards
  • This product is intended to be used as an analytical reference standard
  • Bulk material is available for qualified institutions; please contact our sales department for pricing
Related Products
Certified Reference Material(s)
203966β-Naltrexol-d3 (CRM)
Unlabeled Version(s)
158966β-Naltrexol 187906β-Naltrexol (CRM)
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6β-Naltrexol-d3

Item No. 18350

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • 6β-hydroxy Naltrexone-d3
Technical Information
Formal Name
(5α,6β)-17-(cyclopropylmethyl)-4,5-epoxy-d3-morphinan-3,6,14-triol
CAS Number
1435727-11-9
Molecular Formula
C20H22D3NO4
Formula Weight
346.4
Purity
≥98%
Formulation
A neat solid
SMILES
O[C@]12[C@]3(CCN(C([2H])([2H])C4([2H])CC4)[C@@H]2C5)[C@](OC6=C3C5=CC=C6O)([H])[C@H](O)CC1
InChi Code
InChI=1S/C20H25NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,14-15,18,22-24H,1-2,5-10H2/t14-,15-,18+,19+,20-/m1/s1/i10D2,11D
InChi Key
JLVNEHKORQFVQJ-ZNMQZXPKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    6β-Naltrexol-d3 (Item No. 18350) is an analytical reference material intended for use as an internal standard for the quantification of 6β-naltrexol (Item No. 15896) by GC- or LC-MS. 6β-Naltrexol is the major metabolite of naltrexone (Item Nos. ISO60192 | 15520).1 It is a neutral µ-opioid receptor antagonist (Ki = 94 pM).2,3 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Porter, S.J., Somogyi, A.A., and White, J.M. Kinetics and inhibition of the formation of 6β-naltrexol from naltrexone in human liver cytosol. Br. J. Clin. Pharmacol. 50(5), 465-471 (2000).

    2. Wang, D., Raehal, K.M., Bilsky, E.J., et al. Inverse agonists and neutral antagonists at μ opioid receptor (MOR): Possible role of basal receptor signaling in narcotic dependence. J. Neurochem. 77(6), 1590-1600 (2007).

    3. Porter, S.J., Somogyi, A.A., and White, J.M. In vivo and in vitro potency studies of 6β-naltrexol, the major human metabolite of naltrexone. Addict. Biol. 7(2), 219-225 (2002).