A Certified Reference Material
Features
  • This product is qualified as a Certified Reference Material (CRM) that has been manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards
  • This CRM has been characterized by metrologically valid procedures and may be used as a quantitative analytical reference standard
  • Certificate of analysis provides the certified property values and the associated uncertainties, including a statement of metrological traceability for the certified values
  • Bulk material is available for qualified institutions; please contact our sales department for pricing
Related Products
Reference Material(s)
183506β-Naltrexol-d3
Unlabeled Version(s)
158966β-Naltrexol 187906β-Naltrexol (CRM)
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

6β-Naltrexol-d3 (CRM)

A 100 μg/ml solution in methanol

Item No. 20396

Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • 6β-hydroxy Naltrexone-d3
Technical Information
Formal Name
(5α,6β)-17-(cyclopropylmethyl)-4,5-epoxy-d3-morphinan-3,6,14-triol
CAS Number
1435727-11-9
Molecular Formula
C20H22D3NO4
Formula Weight
346.4
Formulation
A 100 μg/ml solution in methanol
SMILES
O[C@]12[C@]3(CCN(C([2H])([2H])C4([2H])CC4)[C@@H]2C5)[C@](OC6=C3C5=CC=C6O)([H])[C@H](O)CC1
InChi Code
InChI=1S/C20H25NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,14-15,18,22-24H,1-2,5-10H2/t14-,15-,18+,19+,20-/m1/s1/i10D2,11D
InChi Key
JLVNEHKORQFVQJ-ZNMQZXPKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    100 µg

    $262

    Add
    Cayman Chemical
    Forensic Lab Guide Wall Posters

    Discover our collection of drug identification, naming, and metabolism posters for your lab. We offer all of our posters at no cost to help support the forensic community.

    REQUEST YOURS
    Product Description

    6β-Naltrexol-d3 (CRM) (Item No. 20396) is intended for use as an internal standard for the quantification of 6β-naltrexol (Item No. 18790 | 15896) by GC- or LC-MS. 6β-Naltrexol is the major metabolite of naltrexone (Item Nos. ISO60192 | 15520).1 It is a neutral µ-opioid receptor antagonist (Ki = 94 pM).2,3 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Porter, S.J., Somogyi, A.A., and White, J.M. Kinetics and inhibition of the formation of 6β-naltrexol from naltrexone in human liver cytosol. Br. J. Clin. Pharmacol. 50(5), 465-471 (2000).

    2. Wang, D., Raehal, K.M., Bilsky, E.J., et al. Inverse agonists and neutral antagonists at μ opioid receptor (MOR): Possible role of basal receptor signaling in narcotic dependence. J. Neurochem. 77(6), 1590-1600 (2007).

    3. Porter, S.J., Somogyi, A.A., and White, J.M. In vivo and in vitro potency studies of 6β-naltrexol, the major human metabolite of naltrexone. Addict. Biol. 7(2), 219-225 (2002).