An Analytical Reference Material
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  • This product is qualified as a Reference Material that has been manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards
  • This product is intended to be used as an analytical reference standard
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Nimetazepam

Item No. 18352

Restricted Product (Schedule IV)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • Erimin
  • ​Methylnitrazepam
  • Ro 5-3453
Technical Information
Formal Name
1,3-dihydro-1-methyl-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one
CAS Number
2011-67-8
Molecular Formula
C16H13N3O3
Formula Weight
295.3
Purity
≥98%
Formulation
A Neat Solid
SMILES
O=C1CN=C(C2=CC=CC=C2)C3=C(C=CC([N+]([O-])=O)=C3)N1C
InChi Code
InChI=1S/C16H13N3O3/c1-18-14-8-7-12(19(21)22)9-13(14)16(17-10-15(18)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
InChi Key
GWUSZQUVEVMBPI-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
IV
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Nimetazepam (Item No. 18352) is an analytical reference material that is structurally categorized as a benzodiazepine. It is partially metabolized to its desmethyl derivative, nitrazepam (Item No. ISO60201), which acts as a GABA receptor agonist.1,2 Nimetazepam is also converted to glutathione adducts, which have cytotoxic effects on liver cells.2 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yakushiji, T., Fukuda, T., Oyama, Y., et al. Effects of benzodiazepines and non-benzodiazepine compounds on the GABA-induced response in frog isolated sensory neurones. Br. J. Pharmacol. 98(3), 735-740 (1989).

    2. Mizuno, K., Katoh, M., Okumura, H., et al. Metabolic activation of benzodiazepines by CYP3A4. Drug Metab. Dispos. 37(2), 345-351 (2009).