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Explore additional resources to study natural toxins, pollutants including PFAS and 6-PPD-Q, and their biological effects.
ENVIRONMENTAL TOXICOLOGY TOOLS & SERVICESAldicarb is a carbamate pesticide.1 It is an acetylcholinesterase (AChE) inhibitor with an IC50 value of 5 µM.2 Aldicarb induces mortality in the two-spotted spider mite (T. urticae) with an LC50 value of 21 ppm in a slide-dip assay and in the nematode (M. exigua) with an LC50 value of 24 µg/l.3,4 It has been used to study CREB and acetylcholine signaling.5 Formulations containing aldicarb have been used as pesticides in agriculture.
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1. A carbamate insecticide: A case study of aldicarb. Environ. Health Perspect. 102 (Suppl. 11), 23-27 (1994).
2. Selective effects of carbamate pesticides on rat neuronal nicotinic acetylcholine receptors and rat brain acetylcholinesterase. Toxicol. Appl. Pharmacol. 193(2), 139-146 (2003).
3. Comparative toxicities of selected pesticides to bulb mite (Acari: Acaridae) and twospotted spider mite (Acari: Tetranychidae). J. Econ. Entomol. 81(6), 1586-1591 (1988).
4. Organic substances for nematode control in coffee plants. Master's, 36 (2008).
5. Dopamine modulates acetylcholine release via octopamine and CREB signaling in Caenorhabditis elegans. PLoS One 8(8), e72578 (2013).