A DDP-4 inhibitor
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Labeled Version(s)
28203Trelagliptin-13C-d3
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Trelagliptin

Item No. 18504

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluoro-benzonitrile
CAS Number
865759-25-7
Synonyms
  • SYR-472
Molecular Formula
C18H20FN5O2
Formula Weight
357.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 1 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
276 nm
SMILES
O=C(N(C)C(N1CC2=CC(F)=CC=C2C#N)=O)C=C1N3CCC[C@@H](N)C3
InChi Code
InChI=1S/C18H20FN5O2/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)10-13-7-14(19)5-4-12(13)9-20/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3/t15-/m1/s1
InChi Key
IWYJYHUNXVAVAA-OAHLLOKOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Trelagliptin is an inhibitor of dipeptidyl peptidase 4 (DPP-4; IC50 = 4 nM).1 It is greater than 10,000-fold selective for DPP-4 over isopeptidases. Trelagliptin (7 mg/kg) inhibits plasma DPP-4 activity and reduces postprandial plasma insulin levels in Zucker fa/fa rats. Formulations containing trelagliptin have been used in the treatment of type 2 diabetes mellitus.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kushwaha, R.N., Haq, W., and Katti, S.B. Discovery of 17 gliptins in 17-years of research for the treatment of type 2 diabetes: A synthetic overview. Chem. Biol. Interface 4(3), 137-162 (2014).