An internal standard for the quantification of trelagliptin
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Unlabeled Version(s)
18504Trelagliptin
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Trelagliptin-13C-d3

Item No. 28203

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(R)-2-((6-(3-aminopiperidin-1-yl)-3-(methyl-13C-d3)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile
CAS Number
2707203-34-5
Molecular Formula
C17[13C]H17D3FN5O2
Formula Weight
361.4
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
O=C(N([13C]([2H])([2H])[2H])C(N1CC2=CC(F)=CC=C2C#N)=O)C=C1N3CCC[C@@H](N)C3
InChi Code
InChI=1S/C18H20FN5O2/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)10-13-7-14(19)5-4-12(13)9-20/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3/t15-/m1/s1/i1+1D3
InChi Key
IWYJYHUNXVAVAA-GKOPAMJVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $1,319

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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Trelagliptin-13C-d3 is intended for use as an internal standard for the quantification of trelagliptin (Item No. 18504) by GC- or LC-MS. Trelagliptin is an inhibitor of dipeptidyl peptidase 4 (DPP-4; IC50 = 4 nM).1 It is greater than 10,000-fold selective for DPP-4 over isopeptidases. Trelagliptin (7 mg/kg) inhibits plasma DPP-4 activity and reduces postprandial plasma insulin levels in Zucker fa/fa rats. Formulations containing trelagliptin have been used in the treatment of type 2 diabetes mellitus.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kushwaha, R.N., Haq, W., and Katti, S.B. Discovery of 17 gliptins in 17-years of research for the treatment of type 2 diabetes: A synthetic overview. Chem. Biol. Interface 4(3), 137-162 (2014).