An Analytical Reference Material
Features
  • This product is qualified as a Reference Material that has been manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards
  • This product is intended to be used as an analytical reference standard
  • Bulk material is available for qualified institutions; please contact our sales department for pricing
Related Products
Isomer(s)
21937Demoxepam
Parent Compound(s)
14262Clobazam 43237Clobazam (CRM)
Research Tool(s)
18888N-Desmethylclobazam (CRM)
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N-Desmethylclobazam

Item No. 18564

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • nor-Clobazam
  • 4-oxo Lofendazam
Technical Information
Formal Name
8-chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
CAS Number
22316-55-8
Molecular Formula
C15H11ClN2O2
Formula Weight
286.7
Purity
≥98%
Formulation
A neat solid
SMILES
ClC1=CC(N(C2=CC=CC=C2)C(C3)=O)=C(C=C1)NC3=O
InChi Code
InChI=1S/C15H11ClN2O2/c16-10-6-7-12-13(8-10)18(11-4-2-1-3-5-11)15(20)9-14(19)17-12/h1-8H,9H2,(H,17,19)
InChi Key
RRTVVRIFVKKTJK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    N-Desmethylclobazam (Item No. 18564) is an analytical reference material that is structurally categorized as a benzodiazepine. It is a major active metabolite of clobazam, produced primarily by the action of cytochrome P450 isoform 3A4.1 N-Desmethylclobazam positively modulates GABAA receptors (EC50s range from 98 to 151 µM, depending on subunit configuration).2 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. de Leon, J., Spina, E., and Diaz, F.J. Clobazam therapeutic drug monitoring: A comprehensive review of the literature with proposals to improve future studies. Ther. Drug Monit. 35(1), 30-47 (2013).

    2. Hammer, H., Ebert, B., Jensen, H.S., et al. Functional characterization of the 1,5-benzodiazepine clobazam and its major active metabolite N-desmethylclobazam at human GABAA receptors expressed in Xenopus laevis oocytes. PLoS One 10(3), (2015).