A β-AR ligand
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Labeled Version(s)
35560Carazolol-d7
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Carazolol

Item No. 18628

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(9H-carbazol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
CAS Number
57775-29-8
Synonyms
  • BM 51052
  • (±)-Carazolol
Molecular Formula
C18H22N2O2
Formula Weight
298.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 15 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: 5 mg/ml
λmax
224, 243, 286, 319, 332 nm
SMILES
OC(CNC(C)C)COC1=C(C(C=CC=C2)=C2N3)C3=CC=C1
InChi Code
InChI=1S/C18H22N2O2/c1-12(2)19-10-13(21)11-22-17-9-5-8-16-18(17)14-6-3-4-7-15(14)20-16/h3-9,12-13,19-21H,10-11H2,1-2H3
InChi Key
BQXQGZPYHWWCEB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

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    50 mg

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    100 mg

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    Product Description

    Carazolol is a β-adrenergic receptor (β-AR) ligand (Kds = 0.2, 0.03, and 4.47 nM for the human β1-, β2-, and β3-ARs, respectively).1 It reduces epinephrine-induced increases in mean arterial blood pressure and heart rate in conscious pigs when administered at a dose of 10 µg/kg.2 Carazolol has been found in wastewater effluent.3 Formulations containing carazolol have been used to reduce stress in livestock during transport.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Baker, J.G. The selectivity of β-adrenoceptor agonists at human β1-, β2- and β3-adrenoceptors. Br. J. Pharmacol. 160(5), 1048-1061 (2010).

    2. Gregory, N.G., and Wilkins, L.J. The effect of carazolol on the cardiovascular responses to adrenaline in stress sensitive pigs. Vet. Res. Commun. 5(3), 277-283 (1982).

    3. Ternes, T.A. Occurrence of drugs in German sewage treatment plants and rivers. Water Res. 32(11), 3245-3260 (1998).