An α1-AR antagonist
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Labeled Version(s)
30979Doxazosin-d8 (hydrochloride)
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Doxazosin (mesylate)

Item No. 18633

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](2,3-dihydro-1,4-benzodioxin-2-yl)-methanone, monomethanesulfonate
CAS Number
77883-43-3
Synonyms
  • UK 33274-27
Molecular Formula
C23H25N5O5 • CH3SO3H
Formula Weight
547.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.5 mg/mLDMSO: 2 mg/mLDMSO:PBS(pH7.2) (1:1): 0.5 mg/mL
λmax
247, 330 nm
SMILES
COC1=C(OC)C=C(C(N)=NC(N2CCN(C(C3COC(C=CC=C4)=C4O3)=O)CC2)=N5)C5=C1.OS(C)(=O)=O
InChi Code
InChI=1S/C23H25N5O5.CH4O3S/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20;1-5(2,3)4/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26);1H3,(H,2,3,4)
InChi Key
VJECBOKJABCYMF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $49

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    500 mg

    $96

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    1 g

    $129

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    Product Description

    Doxazosin is a non-selective antagonist of α1-adrenergic receptors (α1-ARs; Kis = 3.16, 1, and 3.98 nM for α1A­-, α1B-, and α1D-ARs, respectively).1 It inhibits norepinephrine-induced contractions in isolated rat aorta rings and human prostate strips with pA2 values of 8.8 and 8.2, respectively. Doxazosin inhibits phenylephrine-induced increases in blood pressure and prostatic pressure in anesthetized dogs (pA2 = 7.5 for both). Formulations containing doxazosin have been used in the treatment of benign prostatic hyperplasia and hypertension.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kenny, B.A., Miller, A.M., Williamson, I.J.R., et al. Evaluation of the pharmacological selectivity profile of α1 adrenoceptor antagonists at prostatic α1 adrenoceptors: Binding, functional and in vivo studies. Br. J. Pharmacol. 118(4), 871-878 (1996).