An internal standard for the quantification of doxazosin
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Unlabeled Version(s)
18633Doxazosin (mesylate)
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Doxazosin-d8 (hydrochloride)

Item No. 30979

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl-2,2,3,3,5,5,6,6-d8](2,3-dihydro-1,4-benzodioxin-2-yl)-methanone, monohydrochloride
CAS Number
1219803-95-8
Molecular Formula
C23H17D8N5O5 • HCl
Formula Weight
496.0
Purity
≥99% deuterated forms (d1-d8)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Methanol (1:1): solubleDMSO: soluble
SMILES
COC1=C(OC)C=C(C(N)=NC(N2C([2H])([2H])C([2H])([2H])N(C(C3COC(C=CC=C4)=C4O3)=O)C([2H])([2H])C2([2H])[2H])=N5)C5=C1.Cl
InChi Code
InChI=1S/C23H25N5O5.ClH/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20;/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26);1H/i7D2,8D2,9D2,10D2;
InChi Key
AQAZIYFEPYHLHC-SJEKSWIZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $38

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    1 mg

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    Product Description

    Doxazosin-d8 is intended for use as an internal standard for the quantification of doxazosin (Item No. 18633) by GC- or LC-MS. Doxazosin is a non-selective antagonist of α1-adrenergic receptors (α1-ARs; Kis = 3.16, 1, and 3.98 nM for α1A-, α1B-, and α1D-ARs, respectively).1 It inhibits norepinephrine-induced contractions in isolated rat aortic rings and human prostate strips with pA2 values of 8.8 and 8.2, respectively. Doxazosin inhibits phenylephrine-induced increases in blood pressure and prostatic pressure in anesthetized dogs (pA2 = 7.5 for both). Formulations containing doxazosin have been used in the treatment of benign prostatic hyperplasia and hypertension.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kenny, B.A., Miller, A.M., Williamson, I.J.R., et al. Evaluation of the pharmacological selectivity profile of α1 adrenoceptor antagonists at prostatic α1 adrenoceptors: Binding, functional and in vivo studies. Br. J. Pharmacol. 118(4), 871-878 (1996).