A selective Pim-1 inhibitor
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Isomer(s)
33840Gossypetin 10012600Myricetin
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Quercetagetin

Item No. 18645

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4H-1-benzopyran-4-one
CAS Number
90-18-6
Synonyms
  • 6-hydroxy Quercetin
  • NSC 115916
Molecular Formula
C15H10O8
Formula Weight
318.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH 7.2) (1:4): 1 mg/mlEthanol: 2 mg/ml
λmax
259, 363 nm
SMILES
OC1=C(O)C(O)=C(C(C(O)=C(C2=CC=C(O)C(O)=C2)O3)=O)C3=C1
InChi Code
InChI=1S/C15H10O8/c16-6-2-1-5(3-7(6)17)15-14(22)13(21)10-9(23-15)4-8(18)11(19)12(10)20/h1-4,16-20,22H
InChi Key
ZVOLCUVKHLEPEV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $81

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    1 mg

    $145

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    5 mg

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    Product Description

    Quercetagetin is a flavonol that inhibits Pim-1 with an IC50 value of 0.34 µM.1 It is selective for Pim-1, inhibiting Pim-2, PKA, RSK2, and JNK with IC50 values of 3.45, 21.2, 2.82, and 4.6 µM, respectively.1,2 Quercetagetin has been shown to inhibit Pim-1 activity in intact RWPE2 prostate cancer cells with an ED50 value of 5.5 µM, which led to significant growth inhibition.1 It can also inhibit the growth of additional prostate epithelial cell lines at a potency proportionate to their respective level of Pim-1 protein.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Holder, S., Zemskova, M., Zhang, C., et al. Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase. Mol. Cancer Ther. 6(1), 163-172 (2007).

    2. Baek, S., Kang, N.J., Popowicz, G.M., et al. Structural and functional analysis of the natural JNK1 inhibitor quercetagetin. J. Mol. Biol. 425(2), 411-423 (2013).