Gossypetin

Gossypetin is a flavonoid that has been found in H. sabdariffa and has diverse biological activities.^1,2,3 It inhibits the MAP2K kinases MKK3 and MKK6 in a concentration-dependent manner, as well as induces apoptosis and cell cycle arrest at the G₂ phase in KYSE-450 and KYSE-510 esophageal cancer cells when used at a concentration of 20 µM.¹ Gossypetin scavenges DPPH (Item No. 14805) radicals and inhibits copper-induced lipid peroxidation in cell-free assays.² It reduces high-fat diet-induced increases in serum cholesterol, triglycerides, and LDL-cholesterol levels, as well as decreases aortic extracellular lipid and foam cell deposits in a rabbit model of atherosclerosis when administered at a dose of 10 mg/kg.³

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1. Xie, X., Liu, K., Liu, F., et al. Gossypetin is a novel MKK3 and MKK6 inhibitor that suppresses esophageal cancer growth in vitro and in vivo. Cancer Lett. 442, 126-136 (2019).

2. Chen, J.-H., Tsai, C.-W., Wang, C.-P., et al. Anti-atherosclerotic potential of gossypetin via inhibiting LDL oxidation and foam cell formation. Toxicol. Appl. Pharmacol. 272(2), 313-324 (2013).

3. Lin, H.-H. In vitro and in vivo atheroprotective effects of gossypetin against endothelial cell injury by induction of autophagy. Chem. Res. Toxicol. 28(2), 202-215 (2015).