A sweet taste receptor antagonist
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Lactisole

Item No. 18657

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(4-methoxyphenoxy)-propanoic acid, monosodium salt
CAS Number
150436-68-3
Synonyms
  • na-PMP
Molecular Formula
C10H11O4 • Na
Formula Weight
218.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
226, 289 nm
SMILES
COC1=CC=C(OC(C)C([O-])=O)C=C1.[Na+]
InChi Code
InChI=1S/C10H12O4.Na/c1-7(10(11)12)14-9-5-3-8(13-2)4-6-9;/h3-7H,1-2H3,(H,11,12);/q;+1/p-1
InChi Key
SKORRGYRKQDXRS-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $69

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    10 g

    $127

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    25 g

    $297

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    50 g

    $525

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    Cayman Chemical
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    Product Description

    Lactisole is an antagonist of sweet taste receptors, reducing both sweetness intensity and persistence.1,2 It blocks the activation of the sweet taste receptor T1R3 by natural and synthetic sweeteners and increases the inhibition of T1R2 by umami compounds.3,4 Lactisole can be used to explore the roles of these receptors in diverse pathways, including glucose-induced insulin secretion in pancreatic β-cells and the secretion of glucagon-like peptides by enteroendocrine L-cells.3,5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Johnson, C., Birch, G.G., and MacDougall, D.B. The effect of the sweetness inhibitor 2(-4-methoxyphenoxy)propanoic acid (sodium salt) (Na-PMP) on the taste of bitter-sweet stimuli. Chem.Senses 19(4), 348-358 (1994).

    2. Schiffman, S.S., Booth, B.J., Sattely-Miller, E.A., et al. Selective inhibition of sweetness by the sodium salt of ±2-(4-methoxyphenoxy)propanoic acid. Chem.Senses 24(4), 439-447 (1999).

    3. Hamano, K., Nakagawa, Y., Ohtsu, Y., et al. Lactisole inhibits the glucose-sensing receptor T1R3 expressed in mouse pancreatic β-cells. J. Endocrinol. 226(1), 57-66 (2015).

    4. Shim, J., Son, H.J., Kim, Y., et al. Modulation of sweet taste by umami compounds via sweet taste receptor subunit hT1R2. PLoS One 10(4), (2015).

    5. Ohtsu, Y., Nakagawa, Y., Nagasawa, M., et al. Diverse signaling systems activated by the sweet taste receptor in human GLP-1-secreting cells. Mol. Cell. Endocrinol. 394(1-2), 70-79 (2014).

    6. Sato, S., Hokari, R., Kurihara, C., et al. Dietary lipids and sweeteners regulate glucagon-like peptide-2 secretion. Am. J. Physiol Gastrointest. Liver Physiol. 304(8), 304-308 (2013).