A negative control for SB 202190 and SB 203580
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

SB 202474

Item No. 18749

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[4-ethyl-2-(4-methoxyphenyl)-1H-imidazol-5-yl]-pyridine
CAS Number
172747-50-1
Molecular Formula
C17H17N3O
Formula Weight
279.3
Purity
≥97%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
CCC1=C(C2=CC=NC=C2)N=C(C3=CC=C(OC)C=C3)N1
InChi Code
InChI=1S/C17H17N3O/c1-3-15-16(12-8-10-18-11-9-12)20-17(19-15)13-4-6-14(21-2)7-5-13/h4-11H,3H2,1-2H3,(H,19,20)
InChi Key
MYKGURNPAUBQLJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $156

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    SB 202190 (Item No. 10010399) and SB 203580 (Item No. 13067) are potent, selective inhibitors of the MAP kinases p38α and p38β.1,2 SB 202474 is a structural analog of SB 202190 (Item Nos. Item Nos. 10010399 | 21201) and SB 203580 (Item Nos. 13067 | 13344) that is used as a negative control in studies of p38 inhibition.3,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jiang, Y., Chen, C., Li, Z., et al. Characterization of the structure and function of a new mitogen-activated protein kinase (p38β). The Journal of Biological Chemisty 271(30), 17920-17926 (1996).

    2. Davies, S.P., Reddy, H., Caivano, M., et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351(1), 95-105 (2000).

    3. Lee, J.C., Laydon, J.T., McDonnell, P.C., et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372(6508), 739-746 (1994).

    4. Sweeney, G., Somwar, R., Ramlal, T., et al. An inhibitor of p38 mitogen-activated protein kinase prevents insulin-stimulated glucose transport but not glucose transporter translocation in 3T3-L1 adipocytes and L6 myotubes. The Journal of Biological Chemisty 274(15), 10071-10078 (1999).

    5. Chang, A.Y.W. Pro-life role for c-Jun N-terminal kinase and p38 mitogen-activated protein kinase at rostral ventrolateral medulla in experimental brain stem death. J. Biomed. Sci. 19(1), (2012).